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Candidiasis
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Bacterial Vaginosis
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Trichomonas
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Retained Tampon
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| Vulval itching
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Vulval problems
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Abnormal Bleeding
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Dyspareunia
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Female dysuria
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| Urethral discharge
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Male dysuria
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Penile skin
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Testicular pain
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HIV
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Vaginal Discharge – causes
- Physiological
- Candidiasis
- Bacterial vaginosis
- Trichomonas
- Chlamydia
- Gonorrhoea
- Streptococcal infection - not important unless in final trimester (see midwife)
- Other (retained tampon)
Vaginal Discharge – examination
- Appearance of vulva (red, swollen in thrush)
- Is there any visible discharge? Many women wash thoroughly prior to being examined
- What does the discharge look like?
- Does it look clear/white (normal) or does it resemble other common infections?
- Is there any smell?
- Take samples for chlamydia & gonorrhoea
- Take HVS if you suspect thrush, BV or trich or want confirmation that there is no infection
- Use of pH paper optional
- Chlamydia and gonorrhoea can occur with a normal looking cervix
- They can also produce cervicitis, with purulent discharge and contact bleeding
Physiological
- Clear or white, may be heavy
- Alters during menstrual cycle (if ovulation not suppressed)
- Irritation and soreness uncommon
- Normal sour odour
- May be related to presence of ectropion
- Diagnose when vagina healthy and tests negative
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Candidiasis
- White discharge (curdy, cottage cheese)
- Musty, yeasty odour
- Intensely itchy, irritating, burning, painful
- Swollen labia, inflamed, possible satellite lesions
- Excoriation, shallow ulceration
- External dysuria and superficial dyspareunia
- May be provoked by antibiotics, diabetes, change in vaginal environment
- Can affect male if not using condoms, uncircumcised, no postcoital washing
- Diagnosis made clinically but can be confirmed with HVS Stuarts media
- Treatment clotrimazole pessaries, cream (+hydrocortisone if very sore)
- Oral treatment – fluconazole 50mg daily 7 days or 150mg stat
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Bacterial Vaginosis
- Grey or white discharge, sometimes sticks to vaginal walls
- Fishy odour especially after sex, can vary throughout cycle
- Minimal itching or soreness
- pH >4.5 if using test paper (don’t let speculum lubricant touch paper!)
- Clinical diagnosis, treat with metronidazole 400mg bd 5d
- Alternatives - clindamycin cream (may weaken condoms)
- Or metronidazole gel pv 5 d
- Advise against excessive genital washing/douching
- Not sexually transmitted, partner does not need treating
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Trichomonas
- Rarely seen in primary care in Leicester
- Green frothy discharge with distinctive nasty odour (rotting flesh)
- Itch may be intense because of inflammation
- Vulva & vagina red, with “strawberry cervix”
- Can get a “tide mark” of inflammation extending to inner thighs
- Often a marker for other infections such as gonorrhoea, chlamydia
- Clinical diagnosis, confirmed by HVS Stuarts media
- Treatment with metronidazole 400mg bd 5 days (may need repeating)
- Sexually transmitted, so arrange for partner to be tested and treated
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Retained tampon
- Foul odour, sometimes with bloodstained discharge
- Removing tampon is curative, no other treatment needed
- Check posterior fornix to ensure all removed
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Vulval Itching
- Infections
- Thrush, TV, scabies, crab lice, threadworms
- Dermatological conditions
- Eczema, psoriasis, lichen simplex/sclerosus/planus
- Skin sensitivity
- Detergents, perfumes, deodorants
- Miscellaneous
- Diabetes, post menopausal, pregnancy, urinary incontinence, itch elsewhere, psychological, idiopathic
Examination - Vulval Itching
- Look at vulva
- Excoriation
- Swollen, red labia (with discharge of thrush/TV?)
- Burrows
- Crabs
- Rash eg eczema, psoriasis, lichen sclerosus
- Routine swabs
- Check urine for sugar
Management – Vulval Itching
- Treat infection or other cause
- Advise emollient as soap substitute
- Do not scratch!
- Loose cotton underwear, allow air to circulate
- Avoid chemicals, don’t wash excessively
- Refer for second opinion if unsure of dermatological diagnosis
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Vulval Skin Problems
- Lumps
- Normal – Fordyce glands, skin tags
- Warts, molluscum, boils, sebaceous cysts, nodes
- Ulcers
- Herpes, syphilis, Behcet’s, cancer
- Rash
- Eczema, psoriasis, lichen simplex, sclerosus, planus, VIN
- Candidiasis, TV
Management of vulval problems
- Examination of genitalia & STI screening
Warts
- Podophyllotoxin (Warticon Cream) good for new warts, apply bd for 3 consecutive days each week
- Liquid nitrogen if available
- Imiquimod (Aldara) good for keratinised warts, apply Mon Wed Fri, warn about reaction
- Refer for Hyfrecation under LA or scissoring
- Molluscum
- Not HPV but pox virus
- Characteristic dimple in surface
- Reasonable not to treat
- Liquid N2 or gentle hyfrecation if patient insists
- Boils/seb cysts
- Herpes
- Confirm by culture using viral media
- Treat with aciclovir 200mg x5 for 5 days while waiting for result
- Symptomatic advice, barrier cream, pain relief, local anaesthetic, teabags
- Discuss natural history of infection once diagnosis has been confirmed
- Patient held treatment/prophylactic treatment
- Ulceration which is not typical of herpes
- Refer for second opinion ?syphilis ?sq cell Ca
- Rashes
- Eczema and psoriasis often occur on genitals
- Beware “recurrent thrush itching” could be lichen sclerosus
- Refer for second opinion (Dr Dhar at GUM or vulval dermatology clinic)
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Abnormal Bleeding
- Intermenstrual or post-coital bleeding
- Pregnancy related
- Hormonal contraception related
- Dysfunctional uterine bleeding
- Infections
- Trauma
- Ovulatory spotting
- Gynaecological Neoplasia
- Bleeding diathesis, medication (SSRIs, warfarin)
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Dyspareunia
- Intermenstrual or post-coital bleeding
- Superficial dyspareunia - examination
- Vaginissmus (?psychological)
- Trauma, fissuring, cuts to vulva and hymen
- Vulvitis from thrush, TV or dermatitis
- Ulceration from herpes
- Bartholin’s or other infections
- Painful episiotomy scar
- Lichen sclerosus
- Atrophic changes
- Vestibulitis/vulvodynia
- Deep dyspareunia – needs pelvic exam
- Uterine fibroids or fixed retroverted uterus
- Endometriosis
- Pelvic inflammatory disease (acute or chronic)
- Ovarian cyst or other pelvic masses
- Bowel problems (IBD, constipation)
- Usual STI screening tests and refer for scan or gynae opinion
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Dysuria
- Causes of pain passing urine
- Cystitis/urethritis
- Bacterial UTI
- Trauma
- Stone
- Genital infections (thrush, TV, gonorrhoea, chlamydia, herpes)
- Atrophic vaginitis in older women
- External dermatological problems
Management of Dysuria
- Decide whether genital examination is needed
- Urine sample, dipstick, and send MSU as appropriate
- Treat with fluids, Cranberry juice, and consider antibiotics +/- agents to make urine alkaline
- Offer screening for STIs in high risk groups
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Urethral discharge or irritation
- This is an STI until proven otherwise
- Examine penis for discharge
- Profuse yellow/green pus likely to be gonorrhoea
- Clear or milky discharge likely to be chlamydia or non-specific urethritis
- Swab urethral meatus for gonorrhoea testing
- First pass urine sample for chlamydia testing
- Consider treatment based on clinical findings before results available
- Arrange follow up and partner notification
- Treatment before results
- Azithromycin 1g stat po for NSU & chlamydia
- If you suspect gonorrhoea (purulent profuse discharge), treat with cefixime 400mg stat po AND give azithromycin 1g stat to cover chlamydia too
- Partner notification
- NO sex (oral, genital or anal) even with condoms for at least a week after partner has been treated
- Follow up proven gonorrhoea with test of cure 2wk later
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Dysuria - Men
- In sexually active men, this is an STI until proven otherwise
- Examine penis for discharge, ulceration
- Gently swab (Stuarts) urethral meatus for GC
- First catch urine specimen for chlamydia
- Look for “threads” by swirling urine in bottle
- Treat as non-specific urethritis (Azithro 1g stat)
- Dipstick and MSU if you think it is UTI
- Arrange follow up
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Penile skin problems
- Examine penis
- Normal markings pearly papules, coronal papillae, melanosis, sebaceous cysts, Tyson’s glands
- Lumps & bumps: warts, scabies, molluscum
- Ulcers: herpes, syphilis, carcinoma, Behcet’s
- Changes to glans and foreskin: balanitis/posthitis
Balano-posthitis
- Posthitis – foreskin inflammation
- Balanitis – glans inflammation
- Candida gives red blotches on glans, sometimes with white colonies visible. Foreskin may be tight and fissured. Treat with Daktacort cream bd.
- Circinate balanitis – annular rash, associated with chlamydia. Confirm diagnosis & treat.
- Red velvety patches – balanitis of Zoon or Queyrat. Refer for biopsy then steroid cream
- White scarring – lichen sclerosus (used to be BXO) treat with potent topical steroids +/- circumcision
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Testicular Pain
- Causes
- Epididymo-orchitis
- Torsion
- Referred pain
- Cryptogenic (chronic pelvic pain syndrome)
- Torsion – immediate surgical referral
- Referred pain from kidney stones, neuralgia with shingles or MS
- Chronic pelvic pain syndrome – difficult, leave diagnosis to GUM clinic
Epididymo-orchitis
- Don’t forget mumps
- In sexually active men under 45, likely to be chlamydia or gonorrhoea
- In older men, can be related to urinary tract infection
- Possible blood borne spread (streptococcal, tuberculous)
- Rarely caused by drugs (amiodarone)
- Painful swollen testicles and tubes, usually bilateral, with red, warm scrotum
- Perform usual STI screening tests and send an MSU if indicated
- If clinically chlamydia / GC treat appropriately
- Otherwise, give azithromycin 1g stat and pain relief (paracetamol, ibuprofen)
- Scrotal support and rest
- Be sure you have not missed a torsion
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Role of GP with HIV+ patients
- Alphabet soup therapy
- Drug Interactions
- “Is my cough something to worry about?”
- Be an advocate for your patient
- Interpret complicated medical information
- Pastoral care
HIV shared care
- HIV infection is a chronic disorder
- GPs need to be aware their patient has HIV and what treatment they are taking
- Patients may feel that arrangements for confidentiality are less robust in primary care than in GUM clinics
- Drug interactions – a minefield
Why increase HIV testing?
- 30% of all HIV +ve people in UK are unaware of their infection
- This group usually presents late with more advanced disease
- Often have been seen several times in primary & secondary care without being tested for HIV
- They continue to transmit HIV
HIV testing already routine
- Antenatal testing
- Testing in GU clinic setting
- “Opt out” testing
- SE London prevalence of HIV = 0.6%
- Women from Sub Saharan African = 2.4%
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High risk groups - for targetted testing (more cost-effective)
- Men who have sex with men
- Women with bisexual partners
- Those having had sex with people from high prevalence areas of the world
- IVDUs and their partners
- Blood transfusions overseas
- Sex workers & their clients
High risk conditions - for targetted testing
- Any unusual bacterial, fungal or viral disease:
- infection with tuberculosis
- suspected Pneumocystis carinii pneumonia
- suspected cerebral toxoplasmosis
- oral/oesophageal candidiasis
- hairy leucoplakia
- persistent genital ulceration
- presence of another blood-borne or STI, eg syphilis, hepatitis B
- suspected seroconversion illness (eg flu-like illness, glandular fever with negative EBV serology)
- Odd tumours
- Cerebral lymphoma
- Non Hodgkins lymphoma
- Kaposi
- Unusual skin diseases
- Extensive seborrhoeic dermatitis
- Shingles
- Giant molluscum especially on face
- Persistent generalised lymphadenopathy
- PUO, persistent diarrhoea, night sweats, weight loss
- Unexplained low lymphocyte or platelet count
- Any strange clinical situation, think ?HIV
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Counselling
- Lengthy pre-test HIV counselling is not a requirement
- Provide an opportunity for pre-test discussion to ensure informed consent
- Information leaflets improve take-up
- Negative tests need not be declared on insurance applications
Practical considerations
- HIV antibody testing best on blood
- Saliva will work but needs confirmation
- All positive tests must be repeated
- “Window period”
- Testing & needlestick injuries
- Communicating the results
- Recording the results
Broaching the subject
- Relatively easy when the patient asks for STI screening, or in a “sexy setting”
- Difficult when you suspect HIV and feel a test is needed
- Use “breaking bad news” techniques
- SPIKES (setting up, patient perception, invitation to go there, knowledge, empathy, strategy)
- Be honest, competent and attentive
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